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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-38231 antibody (425-435) (STJ72389)

  • 產(chǎn)品型號(hào)：STJ72389-100
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-38231 antibody (425-435) (STJ72389)
詳情介紹：
Host: Goat
Applications: Pep-ELISA/WB/IHC/FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-38231 (425-435) is suitable for use in ELISA, Western Blot, Immunohistochemistry and Flow Cytometry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-1-3μg/ml
IHC-3.75μg/ml
FC-Flow cytometric analysis of Jurkat cells. 10ug/ml
ELISA-antibody detection limit dilution 1:64000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: SEPTIN4
Gene ID: 5414
Uniprot ID: SEPT4_HUMAN
Immunogen Region: 425-435
Accession Number: NP_004565.1; NP_536341.1, NP_001185642.1
Specificity: This antibody is expected to recognize isoform 1 (NP_004565.1) , 3 (NP_536341.1) and 4 (NP_001185642.1). Amino acid numbering in name refers to NP_004565.1 sequence.
Immunogen Sequence: RNKLTRESGTD
Post Translational Modifications Phosphorylated by DYRK1A. Ubiquitinated by AREL1.
Function Filament-forming cytoskeletal GTPase (Probable). Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP. May also play a role in the regulation of cell fate in the intestine. Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis.via its interaction with XIAP. Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP. Plays an important role in male fertility and sperm motility. During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm. Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development. Required for dopaminergic metabolism in presynaptic autoreceptors.potentially via activity as a presynaptic scaffold protein. Isoform ARTS: Required for the induction of cell death mediated by TGF-beta and possibly by other apoptotic stimuli. Induces apoptosis through binding and inhibition of XIAP resulting in significant reduction in XIAP levels, leading to caspase activation and cell death. Mediates the interaction between BCL2 and XIAP, thereby positively regulating the ubiquitination and degradation of BCL2 and promoting apoptosis.
Protein Name Septin-4
Bradeion Beta
Brain Protein H5
Ce5b3 Beta
Cell Division Control-Related Protein 2
Hcdcrel-2
Peanut-Like Protein 2
Database Links Reactome: R-HSA-111457 O43236-6
Reactome: R-HSA-111469 O43236-6
Cellular Localisation Cytoplasm
Cell Projection
Cilium
Flagellum
Cytoplasmic Vesicle
Secretory Vesicle
Axon
Dendrite
Perikaryon
Synapse
In Platelets
Found In Areas Surrounding Alpha-Granules
Found In The Sperm Annulus
A Fibrous Ring Structure Connecting The Midpiece And The Principal Piece Of The Sperm Flagellum
Expressed And Colocalized With Slc6a3 And Snca In Axon Terminals
Especially At The Varicosities
Isoform Arts: Mitochondrion
Nucleus
While Predominantly Localized In The Mitochondria Under Resting Conditions
Translocates Into The Nucleus After Tgf-Beta Treatment And Apoptosis Induction
Alternative Antibody Names Anti-Septin-4 antibody
Anti-Bradeion Beta antibody
Anti-Brain Protein H5 antibody
Anti-Ce5b3 Beta antibody
Anti-Cell Division Control-Related Protein 2 antibody
Anti-Hcdcrel-2 antibody
Anti-Peanut-Like Protein 2 antibody
Anti-SEPTIN4 antibody
Anti-C17orf47 antibody
Anti-PNUTL2 antibody
Anti-SEP4 antibody
Anti-SEPT4 antibody
Anti-hucep-7 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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