產(chǎn)品詳情
簡單介紹：
Anti-A2M antibody (1200-1300) [S0MR] (STJ11102540)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-A2M (1200-1300) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S0MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | A2M |
| Gene ID: | 2 |
| Uniprot ID: | A2MG_HUMAN |
| Immunogen Region: | 1200-1300 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1200-1300 of human Alpha-2-Macroglobulin (A2M) (P01023). |
| Immunogen Sequence: | QAPSAEVEMTSYVLLAYLTA QPAPTSEDLTSATNIVKWIT KQQNAQGGFSSTQDTVVALH ALSKYGAATFTRTGKAAQVT IQSSGTFSSKFQVDNNNRLL L |
| Tissue Specificity | Secreted in plasma. |
| Function | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| Protein Name | Alpha-2-Macroglobulin Alpha-2-M C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 |
| Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-140837 Reactome: R-HSA-1474228 Reactome: R-HSA-8963896 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Alpha-2-Macroglobulin antibody Anti-Alpha-2-M antibody Anti-C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 antibody Anti-A2M antibody Anti-CPAMD5 antibody Anti-FWP007 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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