產(chǎn)品詳情
簡單介紹：
Anti-AAAS antibody (287-546) (STJ28510)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-AAAS (287-546) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AAAS |
| Gene ID: | 8086 |
| Uniprot ID: | AAAS_HUMAN |
| Immunogen Region: | 287-546 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 287-546 of human AAAS (NP_056480.1). |
| Immunogen Sequence: | GGGVTNLLWSPDGSKILATT PSAVFRVWEAQMWTCERWPT LSGRCQTGCWSPDGSRLLFT VLGEPLIYSLSFPERCGEGK GCVGGAKSATIVADLSETTI QTPDGEERLGGEAHSMVWDP SGERLAVLMKGKPRVQDGKP VILLFRTRNSPVFELLPCGI IQGEPGAQPQLITFHPSFNK GALLSVGWSTGRIAHIPLYF VNAQFPRFSPVLGRAQEPPA GGGGSIHDLPLFTETSPTS |
| Tissue Specificity | Widely expressed. Particularly abundant in cerebellum, corpus callosum, adrenal gland, pituitary gland, gastrointestinal structures and fetal lung. |
| Function | Plays a role in the normal development of the peripheral and central nervous system. Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment. |
| Protein Name | Aladin Adracalin |
| Database Links | Reactome: R-HSA-1169408 Reactome: R-HSA-159227 Reactome: R-HSA-159230 Reactome: R-HSA-159231 Reactome: R-HSA-159236 Reactome: R-HSA-165054 Reactome: R-HSA-168271 Reactome: R-HSA-168276 Reactome: R-HSA-168325 Reactome: R-HSA-168333 Reactome: R-HSA-170822 Reactome: R-HSA-180746 Reactome: R-HSA-180910 Reactome: R-HSA-191859 Reactome: R-HSA-3108214 Reactome: R-HSA-3232142 Reactome: R-HSA-3301854 Reactome: R-HSA-3371453 Reactome: R-HSA-4085377 Reactome: R-HSA-4551638 Reactome: R-HSA-4570464 Reactome: R-HSA-4615885 Reactome: R-HSA-5578749 Reactome: R-HSA-5619107 Reactome: R-HSA-6784531 Reactome: R-HSA-8980692 Reactome: R-HSA-9609690 Reactome: R-HSA-9610379 Reactome: R-HSA-9705671 |
| Cellular Localisation | Nucleus Nuclear Pore Complex Cytoplasm Cytoskeleton Spindle Pole Nucleus Envelope In Metaphase Cells Localizes Within The Spindle With Some Accumulation Around Spindle Poles With The Highest Concentration Between The Centrosome And Metaphase Plate The Localization To The Spindle Is Microtubule-Mediated |
| Alternative Antibody Names | Anti-Aladin antibody Anti-Adracalin antibody Anti-AAAS antibody Anti-ADRACALA antibody Anti-GL003 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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