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  • 產(chǎn)品名稱(chēng)：Anti-FNBP1 antibody (1-210) (STJ112327)

  • 產(chǎn)品型號(hào)：STJ112327
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-FNBP1 antibody (1-210) (STJ112327)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FNBP1 (1-210) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FNBP1
Gene ID: 23048
Uniprot ID: FNBP1_HUMAN
Immunogen Region: 1-210
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human FNBP1 (NP_055848.1).
Immunogen Sequence: MSWGTELWDQFDNLEKHTQW GIDILEKYIKFVKERTEIEL SYAKQLRNLSKKYQPKKNSK EEEEYKYTSCKAFISNLNEM NDYAGQHEVISENMASQIIV DLARYVQELKQERKSNFHDG RKAQQHIETCWKQLESSKRR FERDCKEADRAQQYFEKMDA DINVTKADVEKARQQAQIRH QMAEDSKADYSSILQKFNHE QHEYYHTHIP
Tissue Specificity Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain.
Function May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
Protein Name Formin-Binding Protein 1
Formin-Binding Protein 17
Hfbp17
Database Links Reactome: R-HSA-8856828
Reactome: R-HSA-9013148
Reactome: R-HSA-9013406
Reactome: R-HSA-9013409
Reactome: R-HSA-9696270
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Cortex
Lysosome
Cytoplasmic Vesicle
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Membrane
Clathrin-Coated Pit
Enriched In Cortical Regions Coincident With F-Actin
Also Localizes To Endocytic Vesicles And Lysosomes
Alternative Antibody Names Anti-Formin-Binding Protein 1 antibody
Anti-Formin-Binding Protein 17 antibody
Anti-Hfbp17 antibody
Anti-FNBP1 antibody
Anti-FBP17 antibody
Anti-KIAA0554 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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