產(chǎn)品詳情
簡單介紹：
Anti-IL5 antibody (20-134) (STJ110003)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-IL5 (20-134) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL5 |
| Gene ID: | 3567 |
| Uniprot ID: | IL5_HUMAN |
| Immunogen Region: | 20-134 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-134 of human IL5 (NP_000870.1). |
| Immunogen Sequence: | IPTEIPTSALVKETLALLST HRTLLIANETLRIPVPVHKN HQLCTEEIFQGIGTLESQTV QGGTVERLFKNLSLIKKYID GQKKKCGEERRRVNQFLDYL QEFLGVMNTEWIIES |
| Function | Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively. |
| Protein Name | Interleukin-5 Il-5 B-Cell Differentiation Factor I Eosinophil Differentiation Factor T-Cell Replacing Factor Trf |
| Database Links | Reactome: R-HSA-512988 Reactome: R-HSA-5673001 Reactome: R-HSA-912526 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-5 antibody Anti-Il-5 antibody Anti-B-Cell Differentiation Factor I antibody Anti-Eosinophil Differentiation Factor antibody Anti-T-Cell Replacing Factor antibody Anti-Trf antibody Anti-IL5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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