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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-FADS2 antibody (1-444) (STJ112308)

  • 產(chǎn)品型號(hào)：STJ112308
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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Anti-FADS2 antibody (1-444) (STJ112308)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FADS2 (1-444) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FADS2
Gene ID: 9415
Uniprot ID: FADS2_HUMAN
Immunogen Region: 1-444
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-444 of human FADS2 (NP_004256.1).
Immunogen Sequence: MGKGGNQGEGAAEREVSVPT FSWEEIQKHNLRTDRWLVID RKVYNITKWSIQHPGGQRVI GHYAGEDATDAFRAFHPDLE FVGKFLKPLLIGELAPEEPS QDHGKNSKITEDFRALRKTA EDMNLFKTNHV
Tissue Specificity Expressed in a wide array of tissues, highest expression is found in liver followed by brain, lung, heart, and retina. A lower level is found in breast tumor when compared with normal tissues.lowest levels were found in patients with poor prognostic index.
Function Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively. Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function. Desaturates hexadecanate (palmitate) to produce 6Z-hexadecenoate (sapienate), a fatty acid unique to humans and major component of human sebum, that has been implicated in the development of acne and may have potent antibacterial activity. It can also desaturate (11E)-octadecenoate (trans-vaccenoate, the predominant trans fatty acid in human milk) at carbon 6 generating (6Z,11E)-octadecadienoate. In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates.
Protein Name Acyl-Coa 6-Desaturase
Delta(6 Fatty Acid Desaturase
D6d
Delta(6 Desaturase
Delta-6 Desaturase
Fatty Acid Desaturase 2
Database Links Reactome: R-HSA-2046105
Reactome: R-HSA-2046106
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Acyl-Coa 6-Desaturase antibody
Anti-Delta(6 Fatty Acid Desaturase antibody
Anti-D6d antibody
Anti-Delta(6 Desaturase antibody
Anti-Delta-6 Desaturase antibody
Anti-Fatty Acid Desaturase 2 antibody
Anti-FADS2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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