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產(chǎn)品詳情

  • 產(chǎn)品名稱：Anti-MAP2K4 antibody (301-399) (STJ110035)

  • 產(chǎn)品型號：STJ110035
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡單介紹：
Anti-MAP2K4 antibody (301-399) (STJ110035)
詳情介紹：
Host: Rabbit
Applications: WB/IP
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-MAP2K4 (301-399) is suitable for use in Western Blot and Immunoprecipitation research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IP 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MAP2K4
Gene ID: 6416
Uniprot ID: MP2K4_HUMAN
Immunogen Region: 301-399
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 301-399 of human MAP2K4 (NP_003001.1).
Immunogen Sequence: ATGRFPYPKWNSVFDQLTQV VKGDPPQLSNSEEREFSPSF INFVNLCLTKDESKRPKYKE LLKHPFILMYEERAVEVACY VCKILDQMPATPSSPMYVD
Tissue Specificity Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Post Translational Modifications Activated by phosphorylation on Ser-257 and Thr-261 by MAP kinase kinase kinases (MAP3Ks).
Function Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
Protein Name Dual Specificity Mitogen-Activated Protein Kinase Kinase 4
Map Kinase Kinase 4
Mapkk 4
Jnk-Activating Kinase 1
Mapk/Erk Kinase 4
Mek 4
Sapk/Erk Kinase 1
Sek1
Stress-Activated Protein Kinase Kinase 1
Sapk Kinase 1
Sapkk-1
Sapkk1
C-Jun N-Terminal Kinase Kinase 1
Jnkk
Database Links Reactome: R-HSA-2559580
Reactome: R-HSA-2871796
Reactome: R-HSA-450321
Reactome: R-HSA-5210891
Reactome: R-HSA-5684264
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 antibody
Anti-Map Kinase Kinase 4 antibody
Anti-Mapkk 4 antibody
Anti-Jnk-Activating Kinase 1 antibody
Anti-Mapk/Erk Kinase 4 antibody
Anti-Mek 4 antibody
Anti-Sapk/Erk Kinase 1 antibody
Anti-Sek1 antibody
Anti-Stress-Activated Protein Kinase Kinase 1 antibody
Anti-Sapk Kinase 1 antibody
Anti-Sapkk-1 antibody
Anti-Sapkk1 antibody
Anti-C-Jun N-Terminal Kinase Kinase 1 antibody
Anti-Jnkk antibody
Anti-MAP2K4 antibody
Anti-JNKK1 antibody
Anti-MEK4 antibody
Anti-MKK4 antibody
Anti-PRKMK4 antibody
Anti-SEK1 antibody
Anti-SERK1 antibody
Anti-SKK1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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